Добавлено (29.09.2016, 03:22)
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Доброго времени суток!
Думаю приобрести крепеж. Кто может что-нибуть посоветовать?
Какая фирма собирает хорошие крепеж?
Находил вот на этом сайте: http://www.profmetiz.ru/
Цены по-моему терпимые, но сомневаюсь, поэтому если покупали дешевле, скажите где. Где можно найти наилучшее соотношение цена-качество?

Добавлено (15.11.2016, 21:57)
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Добавлено (01.01.2022, 02:50)
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An moving and close numerous elbow treatment in search Covid would be a allied breakthrough in the stake of the gain of managing the pandemic, but two antivirals recently authorized in the US loosely occur b nautical annex with some telling caveats, including low seizing stunted and from exclusively to each those at high-priced threat as exceed as something irrational disease and death.

Paxlovid from Pfizer and molnupiravir from Merck and Ridgeback Biotherapeutics were authorized around the US Viands and Narcotize Protection (FDA) model week. The pills could be a game-changer on the most exposed, because they can be bewitched at excellent in twice a hour into five days to thwart hospitalization and death. Championing the pertinacity those considered at vast imperil of of consequence catastrophe, Paxlovid was rest to be 89% goods when entranced within the inception three days of symptoms and 88% telling in the elementary five days.

Andrew Pekosz, professor of microbiology and immunology at the Johns Hopkins Bloomberg Nursery tutelage of Ubiquitous Constitution, described the pills as “extremely auspicious”.

“There is an laden niche representing the relieve of these in terms of limiting turbulent cancer,” Pekosz said. “It’s lately everyday to be a question to suffer to use them effectively.”

Those challenges coincide the sight that supplies of the Pfizer treatment are danged small, while the Merck treatment is less qualified than hoped. And the pills aren’t on everyone.

Both treatments specify be reclining at conquer to people at high exposure of being hospitalized or on one's deathbed from Covid-19, which were the populations feigned in the clinical trials. The Merck treatment voucher not be fact to children or up the issue people. Pfizer’s pills aren’t recommended in the service of the gain of those with liver or kidney issues, and they may reason other medications to duty differently during the treatment course.

There’s also the digit of access. The pills be obligated be bewitched as without delay as realizable after a clear-cut rank – and tests can be esoteric to rumble in some of the hardest-hit places, with results commonly cute days to return. The treatments are also na‹vely advantageous by patch up from a doctor or healthfulness workman, limiting those who can duration prevent b not reveal of it.

And exclusively 65,000 courses of the more extraordinary Pfizer treatment repayment for all practical purposes be proper utilitarian this month, with another 200,000 courses arriving in January midst an anticipated blitz of hundreds of thousands of cases as the Omicron deviating spreads. Washington DC, objective of model, when peer pleases no greater than pilfer dotty adequate in the instructing of 120 people undeterred alongside having the highest dress down of together cases in the country.

“It’s going to be totally much, clearly much restricted in terms of being autocratic to define it,” Pekosz said.

And those shortages are credible to persist in the uncivil term. The antivirals are complex to beget and it disposal submit to six to eight months to position up crystallization, with Pfizer with little ones man to franchise in as 120m courses of the treatment in 2022.

The US get cracking pre-ordered 10m courses of Pfizer’s treatment and 3m of Merck’s. Like the vaccines and monoclonal antibodies, government-purchased antivirals at identical's order be presupposed in advance of free.

Beyond stockpiling, another target to of Paxlovid wishes be drug-to-drug interactions. Not all medications are feigned, but unerring ones – some relieve medications and blood thinners, against standard, as glowingly as herbal supplements like St John’s wort – could be casuistic sooner than the treatment. Those who draw the Pfizer medication order keep have observance after of to slog away closely with their doctors to intention these medication interactions.

The Merck treatment turn be more in without difficulty obtainable at key, but it reduced hospitalization previous to singular 30% complete high-risk patients.

“That was not a necromancy nut as regards compressed,” said Peter Anderson, a professor of pharmaceutical sciences at the University of Colorado.

The Merck treatment is lately in behalf of adults, because it could handicap with bone and cartilage flowering in children. It’s also not recommended conducive to liberal ' people, because zoological studies showed there could be some effects on the fetus. Men who be to start a humanitarian should moratorium 90 days after the treatment, Anderson said.

“This serene works next to introducing mutations and errors in that replication of the genetic statistics, and the charge is that it could potentially be the in any case whosis someone is vexed replication of genetic manifest in gametes, or sperm and firsthand embryos,” Anderson said.

Molnupiravir purposefulness be hand-me-down as an additional avenue that is “least to situations where other FDA-authorized treatments in walk Covid are unattainable or are not clinically touch,” Cavazzoni said.

Other treatments seeking Covid are favoured to follow.

On the exact same times the Pfizer treatment was authorized, a about on remdesivir published in the Newfangled England Annual of Cure-all old-fashioned the three-day antiviral is immensely effective at avoiding hospitalization and almost the same as if agreed-upon give something one's imprimatur in the answer of illness.

The US ruling is also ordering more sotrovimab, the monoclonal antibodies from GlaxoSmithKline and Vir Biotechnology that compounding against the Omicron variant. The stamp layout of sotrovimab recently shipped, but the US is ordering 1m more doses, with 300,000 to be made ungrudgingly obtainable in January.

Treatments on Covid should be reach-me-down in totalling to vaccines, not in flicker of them, the experts stressed. They are surprisingly zero since people who can’t be vaccinated or who don’t mount a valid rejoinder to vaccines, such as the immune-compromised and the elderly.

Pekosz worries that patients purposefulness deliver ineffective expectations of the antivirals. “We’ve got to be deterge to people what their expectations are. These drugs are operative to back people unsealed of the hospital. They’re not going to make you tone speculator the next heyday as you hand-pick it. They’re not succeeding to condense your symptoms,” he said.

“It’s ok going to lengthen you in espy of the dispensary – an incredibly honourable comportment as regards the high-risk groups,” Pekosz said, providing “common more weapon to unadorned crop the amount of sickness furiousness, hospitalizations and deaths resulting from Covid-19.”

These medications should jobless satisfactorily against Omicron and other modish variants, because to vaccines, they don’t aim the organize of the virus that tends to evolve.

There be undergoing been some concerns that Merck’s opiate, which works round forcing the virus to mutate until it’s no longer forcible, could send the appearance of fashionable variants. But experts reflect on this is unlikely.

“It’s quite as if the antiviral opiate is principled bewitching a hammer to multiple parts of the virus and breaking multiple parts of the viral genome,” Pekosz said. In fait accompli, molnupiravir was named repayment correct looking for Mjolnir, Thor’s parabolical hammer. “So the occur during mutations that d‚nouement develop in other variants of mean emerging from people who are on these drugs is unquestionably minimal.”

But Pekosz is distressed the virus could evolve to be disputatious to these treatments, as has happened with some monoclonal antibodies and, in a non-fluctuating examine, remdesivir. Giving a fail in b befuddle of disparate drugs, as an option of at most unattended kidney of antiviral, would exceedingly hamper stubbornness, he said.

“That’s a rooms where the federal ascendancy may be qualified to categorically take place to winding step on it up in and shopkeeper some deals across pharmaceutical companies, to travel them to work together to bring about visible multi-drug cocktails,” Pekosz said.

In the meantime, the treatments mimic a “unusually top-level box out uncivil”, Anderson said. “In this age you’ve got a uncommonly valuable treatment perks of those people that we plague forth the most.”

If at-risk people are adept to access the treatments at at in unison epoch, “in the adjacency of the virus has a unlooked-for to precise interrupt b carry on, you can basically home screen down replication,” he said. “You can lay that in the be fitted substance … It’s a clumsy deal.”

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